Functional Repression of cAMP Response Element in 6-Hydroxydopamine-treated Neuronal Cells
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چکیده
منابع مشابه
Protein kinase Dyrk1 activates cAMP response element-binding protein during neuronal differentiation in hippocampal progenitor cells.
Dyrk is a dual specific protein kinase thought to be involved in normal embryo neurogenesis and brain development. Defects/imperfections in this kinase have been suggested to play an important role in the mental retardation of patients with Down's syndrome. The transcriptional factor cAMP response element-binding protein (CREB) has been implicated in the formation of many types of synaptic plas...
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The effect of 6-hydroxydopamine on growth and viability of cultured cells of sympathetic (neuroblastoma), glial, and fibroblast origin was examined. In contrast to previous reports, inhibition of growth was not specific to neuroblastoma cells. The degree of inhibition was correlated with permeability of cell membrane to dopamine-14C or 6-hydroxydopamine-14 C and with sensitivity of the membrane...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2006
ISSN: 0021-9258
DOI: 10.1074/jbc.m602632200